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To test whether hepatic CYP8B1 plays a primary role in the regulation of glucose metabolism by T3, we performed a CYP8B1-knockdown experiment using adeno-associated virus (AAV) expressing shRNA specific for Cyp8b1

However, the underlying molecular basis remained unknown

Interestingly, intragastric administration reduced food intake by 21% in 24 hours, while intravenous injection did not lead to any behavioral changes in food intake, suggesting that the effect of butyrate on feeding behavior is indirect through a mechanism involving gut-brain neural circuits [119]

It is a once-weekly subcutaneous injection delivered by a small needle